Neuronal cell death in the central nervous system has always been a challenging process to decipher. In normal physiological conditions, neuronal cell death is restricted in the adult brain, even in aged individuals. However, in the pathological conditions of various neurodegenerative diseases, cell death and shrinkage in a specific region of the brain represent a fundamental pathological feature across different neurodegenerative diseases. In this review, we will briefly go through the general pathways of cell death and describe evidence for cell death in the context of individual common neurodegenerative diseases, discussing our current understanding of cell death by connecting with renowned pathogenic proteins, including Tau, amyloid-beta, alpha-synuclein, huntingtin and TDP-43.
La morte delle cellule neuronali nel sistema nervoso centrale è sempre stata un processo difficile da decifrare. In condizioni fisiologiche normali, la morte delle cellule neuronali è limitata nel cervello adulto, anche negli individui anziani. Tuttavia, nelle condizioni patologiche di varie malattie neurodegenerative, la morte cellulare e il restringimento in una regione specifica del cervello rappresentano una caratteristica patologica fondamentale in diverse malattie neurodegenerative. In questa recensione, esamineremo brevemente i percorsi generali della morte cellulare e descriveremo le prove della morte cellulare nel contesto di singole malattie neurodegenerative comuni, discutendo la nostra attuale comprensione della morte cellulare collegandoci con rinomate proteine patogene, tra cui Tau, beta-amiloide , alfa-sinucleina, huntingtina e TDP-43.
MECCANISMI DI MORTE CELLULARE PROGRAMMATA NELLE PRINCIPALI MALATTIE NEURODEGENERATIVE
DI MURO, FRANCESCA
2020/2021
Abstract
Neuronal cell death in the central nervous system has always been a challenging process to decipher. In normal physiological conditions, neuronal cell death is restricted in the adult brain, even in aged individuals. However, in the pathological conditions of various neurodegenerative diseases, cell death and shrinkage in a specific region of the brain represent a fundamental pathological feature across different neurodegenerative diseases. In this review, we will briefly go through the general pathways of cell death and describe evidence for cell death in the context of individual common neurodegenerative diseases, discussing our current understanding of cell death by connecting with renowned pathogenic proteins, including Tau, amyloid-beta, alpha-synuclein, huntingtin and TDP-43.File | Dimensione | Formato | |
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https://hdl.handle.net/20.500.12075/1082