BACKGROUND: Cystic fibrosis (CF) is a multi-systemic disease that affects the lungs, digestive system, sweat glands and the reproductive tract. Cough is one of the symptoms that accompany CF patients on a daily basis. In clinical practice, a specific tool such as the Leicester Cough Questionnaire (LCQ) may be essential to assess the impact of cough on the patient's life and to monitor the symptom itself. Since the LCQ has not yet been validated in Italy, we have set ourselves the goal of validation in the Italian language and in particular in adult CF patients. MATERIAL AND METHODS: After obtaining the approval of the Ethics Committee, two processes were followed, one of translation and cultural adaptation followed by another of validation of the questionnaire. For the translation procedure, the Beaton and Wild guidelines were applied, at the end of which a final version in Italian was obtained which was then submitted to patients during the validation phase, together with two other questionnaires, the Cough VAS and the CFQ-R. RESULTS: The study is nearing completion, it is estimated that the results of the statistical analysis will be obtained by December 2021, when the administration of the questionnaires will be completed. Evaluating the preliminary results obtained, we can say that the total score of the LCQ is reproducible after one week. CONCLUSION: This work, carried out since February 2021 and still in progress today, has shown us how an instrument for assessing the quality of life of the patient is fundamental in cystic fibrosis; the cough symptom represents a characteristic element of the disease and has a very high impact on everyday life. Preliminary results indicate that the Leicester cough questionnaire in its Italian version may soon become a useful tool in the daily assessment of the CF patient.
Background e razionale: La fibrosi cistica (FC) è una malattia multi sistemica che colpisce i polmoni, l’apparato digerente, le ghiandole sudoripare e il tratto riproduttivo. La tosse è uno dei sintomi che accompagnano quotidianamente la vita dei pazienti affetti da FC. Nella pratica clinica può essere fondamentale uno strumento specifico come il Leicester Cough Questionnaire (LCQ) per valutare l'impatto della tosse sulla vita del paziente e per monitorare il sintomo stesso. Poiché il LCQ non è ancora stato validato in Italia ci siamo posti come obiettivo la validazione in lingua italiana e in particolare in pazienti adulti FC. Materiali e metodi: Dopo aver ottenuto l’approvazione del Comitato Etico delle Marche sono stati seguiti due processi, uno di traduzione e adattamento culturale seguito da un altro di validazione del questionario. Per la procedura di traduzione sono state applicate le linee guida Beaton e Wild, al termine della quale si è ottenuta una versione finale in italiano che è stata poi sottoposta ai pazienti durante la fase di validazione, insieme ad altri due questionari, la Cough Visual Analogue Scale (Cough VAS) e il Cystic Fibrosis Questionnaire Revised (CFQ-R). Risultati: Lo studio è in fase di completamento, si stima di ottenere i risultati dell’analisi statistica entro dicembre 2021, quando la somministrazione dei questionari sarà completata. Valutando i risultati preliminari ottenuti, possiamo dire che il punteggio totale del LCQ risulta riproducibile dopo una settimana. Conclusioni: Questo lavoro, eseguito da febbraio 2021 e ad oggi ancora in corso ci ha dimostrato come uno strumento di valutazione della qualità della vita del malato sia fondamentale in fibrosi cistica; il sintomo tosse rappresenta un elemento caratteristico della malattia ed ha un elevatissimo impatto nella quotidianità. I risultati preliminari indicano che il questionario della tosse di Leicester nella sua versione italiana può a breve diventare uno strumento utile nella valutazione quotidiana del paziente FC.
Validazione della versione italiana del Leicester Cough Questionnaire in pazienti affetti da Fibrosi Cistica
DANESE, MARIACHIARA
2020/2021
Abstract
BACKGROUND: Cystic fibrosis (CF) is a multi-systemic disease that affects the lungs, digestive system, sweat glands and the reproductive tract. Cough is one of the symptoms that accompany CF patients on a daily basis. In clinical practice, a specific tool such as the Leicester Cough Questionnaire (LCQ) may be essential to assess the impact of cough on the patient's life and to monitor the symptom itself. Since the LCQ has not yet been validated in Italy, we have set ourselves the goal of validation in the Italian language and in particular in adult CF patients. MATERIAL AND METHODS: After obtaining the approval of the Ethics Committee, two processes were followed, one of translation and cultural adaptation followed by another of validation of the questionnaire. For the translation procedure, the Beaton and Wild guidelines were applied, at the end of which a final version in Italian was obtained which was then submitted to patients during the validation phase, together with two other questionnaires, the Cough VAS and the CFQ-R. RESULTS: The study is nearing completion, it is estimated that the results of the statistical analysis will be obtained by December 2021, when the administration of the questionnaires will be completed. Evaluating the preliminary results obtained, we can say that the total score of the LCQ is reproducible after one week. CONCLUSION: This work, carried out since February 2021 and still in progress today, has shown us how an instrument for assessing the quality of life of the patient is fundamental in cystic fibrosis; the cough symptom represents a characteristic element of the disease and has a very high impact on everyday life. Preliminary results indicate that the Leicester cough questionnaire in its Italian version may soon become a useful tool in the daily assessment of the CF patient.File | Dimensione | Formato | |
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TESI LCQ LAUREA.pdf
embargo fino al 16/11/2024
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https://hdl.handle.net/20.500.12075/786